Few buildings would ever hold as important a symbolic place as this one. It was rebuilt on the original site to the specifications discovered in painstakingly exploring it's remnant parts. Maryland has long been taught in history books to elementary school children as the colony founded on religious tolerance because a Protestant king gave Catholics a charter to establish it. As in most things, the truth is far less generous. Whatever initial freedoms of worship Maryland's Catholic community experienced, they were short-lived and centered around this parish. (by 1704 the church was padlocked and open practice of Papist religion was banned and persecuted as a cultural norm.)
As fate would have it, I participated in a Smithsonian sponsored project for teachers of Social Studies in the mid-1990's and one day was given to our meeting and working with Doug Owsley. He had the skull of one of the members of St. Mary's three in his lab at the time and we were privileged to examine it up close and personal as he lectured us one what we had learned about this discovery. All of the remains have since be reinterred in the crypt below this building. Owsley's life is the inspiration for the TV series "Bones," as an aside.